|
rs9340799
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Variations in the -397T>C (rs2234693) and -351A>G (rs9340799) single nucleotide polymorphisms of the estrogen alpha receptor (ESR1) gene were found to be strongly associated with risk of ischemic heart disease, although not all studies could replicate this finding.
|
18309176 |
2008 |
|
rs884164
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Importantly, analysis of a human cohort with suspected coronary artery disease showed that a common noncoding polymorphism, rs884164, decreases the cardiac expression of PLIN5 and is associated with reduced heart function following myocardial ischemia, indicating a role for Plin5 in cardiac dysfunction.
|
27376234 |
2016 |
|
rs872129
|
|
|
0.010 |
GeneticVariation |
BEFREE |
High YKL-40 levels (>85 ng/ml) and rs872129 were associated with an increased mortality risk of ischemic stroke, but high YKL-40 levels were also inverse related with the risk of incidence of IHD.
|
22937056 |
2012 |
|
rs7944926
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Two 25(OH)D reducing genetic variants in the DCHR7 gene (rs7944926 and rs11234027) and two in the CYP2R1 gene (rs10741657 and rs12794714) were genotyped in 92 416 participants of Danish descent, of whom 14 455 developed ischaemic heart disease (ICD-8:410-414; ICD-10:I20-I25) and 7061 myocardial infarction (ICD-8:410: ICD-10:I21-I22) from 1977 through 2011.
|
25981321 |
2015 |
|
rs7903146
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Pilot cohort study on the potential role of TCF7L2 rs7903146 on ischemic heart disease among non-diabetic kidney transplant recipients.
|
28299838 |
2017 |
|
rs77375493
|
|
|
0.010 |
GeneticVariation |
BEFREE |
JAK2 V617F somatic mutation positives versus negatives had higher erythrocyte (P = 2 × 10(-5) ), thrombocyte (P = 2 × 10(-16) ), and leucocyte (P = 4 × 10(-9) ) counts, and had 2·7-/2·5-fold risk of cancer (prevalent/incident), 44-/28-fold risk of haematological cancer, 221-/97-fold risk of myeloproliferative cancer, 2·2-/1·2-fold risk of ischaemic heart disease, and 3·1-/1·0-fold risk of venous thromboembolism.
|
23116358 |
2013 |
|
rs753152
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Five of the SNPs (rs77035639, rs3815524, rs75380157, rs147565266, and rs753152) showed no significant association with obesity, ischemic heart disease, hypertension, dyslipidemia, and diabetes.
|
28904253 |
2017 |
|
rs752596535
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We analyzed the OLR1 gene and found a single nucleotide polymorphism (SNP), G501C, in patients with ischemic heart disease from a single family, which resulted in the missense mutation of K167N in LOX-1 protein.
|
12646194 |
2003 |
|
rs751141
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We genotyped participants from the Copenhagen City Heart Study (n=10 352), the Copenhagen General Population Study (n=26 042), the Copenhagen Carotid Stroke Study (n=398 cases+796 control subjects), and the Copenhagen Ischemic Heart Disease Study (n=4901 cases+9798 control subjects) for the R103C, R287Q, and Arg(402-403ins) variants in the EPHX2 gene and recorded hospital admissions due to ischemic stroke, myocardial infarction, and ischemic heart disease.
|
19940276 |
2010 |
|
rs750249283
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Next, we genotyped 10 237 individuals from the Copenhagen City Heart Study for the identified variants and determined the effect on lipid and lipoprotein levels and on risk of myocardial infarction (MI) and ischemic heart disease (IHD). g.-376C>T, g.-311T>A, and Ser630Leu predicted risk of MI in the Copenhagen City Heart Study, with hazard ratios of 2.2 (95% confidence interval: 1.2-4.3), 1.7 (1.0-2.9), and 7.5 (1.9-30), respectively.
|
22155456 |
2012 |
|
rs745738344
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The emerging data are quite conflicting and do not provide definitive evidence for a role of these gene variants in the pathogenesis of IHD; a possible exception is the G252A and polymorphism in the TNF-beta gene (also known as lymphotoxin-alpha) which, in a comprehensive genome-scan linkage analysis of unrelated Japanese, but not in a smaller German population, was linked to myocardial infarction.
|
15760675 |
2005 |
|
rs738409
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We used instrumental variable analysis based on two single nucleotide polymorphism (SNPs) HSD17B13/MAPK10 (rs6834314) and PNPLA3/SAMM50 (rs738409) to assess the associations of ALT (U/L) with IHD, diabetes and other CVD risk factors in the Guangzhou Biobank Cohort Study (GBCS).
|
28007909 |
2017 |
|
rs738409
|
|
|
0.020 |
GeneticVariation |
BEFREE |
PNPLA3 I148M was associated with a stepwise increase in liver fat content of up to 28% in MM vs. II-homozygotes (P-trend = 0.0001) and with ORs of 2.03 (1.52-2.70) for NAFLD (P = 3×10-7), 3.28 (2.37-4.54) for cirrhosis (P = 4×10-12), and 0.95 (0.86-1.04) for IHD (P = 0.46).
|
29228164 |
2018 |
|
rs72653706
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In 4 studies including 66 831 participants and 13 642 cases with ischemic vascular events, heterozygosity for ABCC6 R1141X did not associate with risk of IHD, myocardial infarction, ICVD, or ischemic stroke.
|
21831958 |
2011 |
|
rs7043199
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Based on 9 SNPs independently predicting VEGF (rs1740073 [<i>C6orf223</i>], rs2375981 [<i>KCNV2</i>], rs2639990 [<i>ZADH2</i>], rs4782371 [<i>ZFPM1</i>], rs6921438 [<i>LOC100132354</i>], rs7043199 [<i>VLDLR-AS1</i>], rs10761741 [<i>JMJD1C</i>], rs6993770 [<i>ZFPM2</i>], and rs114694170 [<i>MEF2C</i>]), VEGF was unrelated to IHD (odds ratio 0.99 per log-transformed pg/mL, 95%CI 0.96-1.02) using inverse variance weighting.
|
28765276 |
2017 |
|
rs699947
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Moreover, VEGF rs699947 and rs2010963 polymorphisms may serve as genetic biomarkers of poor collateral circulation after myocardial ischemia.
|
30317903 |
2018 |
|
rs6993770
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Based on 9 SNPs independently predicting VEGF (rs1740073 [<i>C6orf223</i>], rs2375981 [<i>KCNV2</i>], rs2639990 [<i>ZADH2</i>], rs4782371 [<i>ZFPM1</i>], rs6921438 [<i>LOC100132354</i>], rs7043199 [<i>VLDLR-AS1</i>], rs10761741 [<i>JMJD1C</i>], rs6993770 [<i>ZFPM2</i>], and rs114694170 [<i>MEF2C</i>]), VEGF was unrelated to IHD (odds ratio 0.99 per log-transformed pg/mL, 95%CI 0.96-1.02) using inverse variance weighting.
|
28765276 |
2017 |
|
rs699
|
|
|
0.020 |
GeneticVariation |
BEFREE |
M235T genotype did not predict systolic or diastolic blood pressure or risk of ischemic heart disease or myocardial infarction in either ethnic group.
|
12805070 |
2003 |
|
rs699
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In six large case-control studies, the M235T and T174M angiotensinogen mutations were not consistently associated with increased (or decreased) risk for ischemic heart disease, myocardial infarction, or ischemic cerebrovascular disease.
|
11352695 |
2001 |
|
rs6921438
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Based on 9 SNPs independently predicting VEGF (rs1740073 [<i>C6orf223</i>], rs2375981 [<i>KCNV2</i>], rs2639990 [<i>ZADH2</i>], rs4782371 [<i>ZFPM1</i>], rs6921438 [<i>LOC100132354</i>], rs7043199 [<i>VLDLR-AS1</i>], rs10761741 [<i>JMJD1C</i>], rs6993770 [<i>ZFPM2</i>], and rs114694170 [<i>MEF2C</i>]), VEGF was unrelated to IHD (odds ratio 0.99 per log-transformed pg/mL, 95%CI 0.96-1.02) using inverse variance weighting.
|
28765276 |
2017 |
|
rs6834314
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We used instrumental variable analysis based on two single nucleotide polymorphism (SNPs) HSD17B13/MAPK10 (rs6834314) and PNPLA3/SAMM50 (rs738409) to assess the associations of ALT (U/L) with IHD, diabetes and other CVD risk factors in the Guangzhou Biobank Cohort Study (GBCS).
|
28007909 |
2017 |
|
rs6749704
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The aim of this study was to evaluate the CXCL10, CCL20 and CCL22 levels and the single nucleotide polymorphisms (SNPs) rs4508917, rs6749704 and rs4359426 in chemokine genes in patients with IHD to clarify any association.
|
27152707 |
2016 |
|
rs6742078
|
|
|
0.010 |
GeneticVariation |
BEFREE |
UGT1A1 rs6742078 TT versus GG genotype was associated with 95% increased bilirubin levels (P < 0.001); TT versus GG genotype was associated with odds ratios (ORs) of 1.03 (95% CI, 0.96-1.11; P = 0.73) for IHD and 1.01 (95% CI, 0.92-1.12; P = 0.68) for MI.
|
22805420 |
2013 |
|
rs662
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Using self-reported data on ischemic heart disease to evaluate the impact of the PON 192Q/R polymorphism on susceptibility to CHD, we found only a nonsignificant trend of 192RR homozygosity in women being a risk factor.
|
15241482 |
2004 |
|
rs6025
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Prothrombin G20210A heterozygosity alone and in combination with Factor V Leiden R506Q heterozygosity predicts 1.5 and 6.0 fold risk of IHD compared to non-carriers.
|
19524925 |
2010 |